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The Turkish Journal of Gastroenterology
2000, Volume 11, No 4, Page(s)
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The effect of reliefband acustimulation on nausea and vomiting at gastroscopy
Ceyhan Ayşegül1, Baltacı Bülent1, Erten Ahmet2, Kavaklıoğlu Özlem1, Çetinbaş Reşat1, Acar Yaşar2, Ünal Nurten1
Ankara Hospital, Departments of Anaesthesiology1 and Gastroenterology2, Ankara
Keywords: Gastroskopi, sedasyon, akustimülasyon.
Summary
Background/aims: This study compared the effect of Reliefband acustimulation and a sedative dose of midazolam on nausea and vomiting at gastroscopy, which is a serious problem for patients and physicians alike. Methods: Seventy-five patients were randomized into three groups of 25 patients and topical xylocaine was used on all of them. Ten minutes prior to gastroscopy, Group 1 patients had acustimulation applied to the P6 (Neiguan) point using Reliefband, Group 2 patients received midazolam 0.08 mg/kg intravenously while Group 3 was chosen as a control group and only gastroscopy was performed. Nausea and vomiting were noted using Bellivalli score. Results: Nausea and vomiting were significantly less in the reliefband acustimulation group while patient comfort was significantly higher in the midazolam group due to sedation. Conclusions: Acustimulation is a good alternative to sedation for relief of nausea and vomiting.
  • Top
  • Summary
  • Introduction
  • Materials And Methods
  • Discussion
  • Conclusion
  • References
  • Introduction
    Gastroscopy is a very important diagnostic procedure which is of vital importance in the early diagnosis of many diseases. However, the nausea and vomiting associated with this operation may alienate the patient, resulting in delay of diagnosis. Moreover, nausea and vomiting lengthen the procedure and impede the physician.

    Acustimulation has recently been accepted as a good alternative to the use of midazolam for the prevention of nausea and vomiting during gastroscopy. Ease of application, absence of side-effects and cost-effectiveness are very important criteria considered by all authorities in evaluating these approaches.

    In this study, acustimulation applied to the P6 (Neiguan) point was compared with sedative doses of midazolam for the relief of nausea and vomiting.
  • Top
  • Summary
  • Introduction
  • Materials And Methods
  • Discussion
  • Conclusion
  • References
  • Materials And Methods
    The study included 75 patients aged 20 – 60 with years gastric disturbances, all included in, following patient consent and hospital ethics committee approval. Patients with a pacemaker or pregnant in the second or third trimester were excluded. Prior to gastroscopy, arterial pressure and pulse were measured in order to calculate the mean arterial pressure (MAP) and those outside normal ranges were excluded from the study. Emotional status and quantity of oropharyngeal secretions were assessed by direct questioning. Patients were randomly divided into three groups and 10% Xylocaine was applied topically.

    Figure 1:

    In the first group (Group RB), Reliefband was applied to the P6 (Neiguan) acupuncture point (Figures 1 and 2). Acustimulation in C mode (exploding for 2 seconds, continuously, 0.5 Hz) was started 10 minutes before gastroscopy and sustained during the procedure.

    Figure 2:

    In the second group (Group M), 0.08 mg/kg midazolam was given intravenously to the patients 10 minutes prior to the prodecure.

    The third group was accepted as a control group (Group C) and neither of the above were used prior to gastroscopy.

    Bellivalli scores were used in the evaluation of nausea and vomiting;

    0: No nausea and vomiting
    1: Nausea (+)
    2: Retching (+)
    3: Vomiting (+)

    Following gastroscopy, the patients were directly asked to evaluate the method in terms of nausea and vomiting.

    Mann – Whitney U Test, Kruskal Wallis Variant Analyses and Chi- Square Test were used in the statistical analyses.
  • Top
  • Summary
  • Introduction
  • Materials And Methods
  • Discussion
  • Conclusion
  • References
  • Discussion
    Gastroscopy is used for diagnosis and monitoring of therapy in many diseases. In particular, it is a unique diagnostic tool in malignant diseases where early diagnosis is of vital importance. However, the nausea and vomiting which accompany this procedure alienates both physician and patient, with many patients refusing endoscopy and a resultant delay in diagnosis. The physician is also hampered by patient retching, which lengthens procedure time.

    A number of methods of nausea and vomiting prevention have been tried to date, the most favoured of which is a sedative dose of midazolam. Although it does not have antiemetic properties, the decrease in oropharyngeal irritation indirectly reduces nausea and vomiting. However, even in minimal doses, midazolam carries the risk of hypersensitivity and respiratory depression and requires the presence of anesthesiologist throughout the procedure.

    It has recently been said that, acupuncture is said to be very effective for prevention of nausea and vomiting, but there are few studies on the subject. Studies on the P6 (Neiguan) acupuncture point are the most interesting in this respect. This point is 2T sun away from the wrist fold, at middle line and 6 mm. deep between the tendons of m.palmaris longus and m.flexor carpi radialis. 1T is accepted as the width of the thumb (1-3).

    In a previous study that was carried out in our clinic, acupuncture was found to be effective in prophylaxis of nausea and vomiting at gynecologic laparoscopic operation. Ease of performance and cost-effectiveness of the method supports acceptance of it as an alternative therapy by many authorities (4).

    A group of investigators studying acupuncture prior to induction in gynecologic laparoscopy, reported that this method significantly reduces nausea and vomiting (5).

    Dundee and Mc Millan found acupuncture application on the P6 (Neiguan) acupuncture point prevented postoperative nausea and vomiting (6). At the same time, transcutaneous electrical nerve stimulation (TENS) applied to traditional Chinese acupuncture points is also accepted as acustimulation.

    Acustimulation has been found at least and sometimes more effective than acupuncture in many instances and with a wide spectrum of conditions such as postoperative pain, morning nausea, cancer chemotherapy, motion sickness etc. (7,8). It was for this reason that Reliefband was created with the application of TENS technology, minimizing it to a wriststrop. An electric current is created by TENS tool and enters the selected part of the body (8).

    Fasiolaki et al. demonstrated that transcutaneus electrical nerve stimulation reduces the incidence of nausea and vomiting and can therefore be used as an alternative to drugs (9).

    Nausea and vomiting that cannot be prevented by antiemetics alone occurring after cancer chemotherapy was reported point by Dundee to improve when drugs were accompanied by acustimulation on the P6 (Neiguan) acupuncture point (10). Saller demonstrated that TENS application to the P6 (Neiguan) acupuncture point increases the effect of metoclopropamide significantly in cisplatin chemotherapy (11). Mc Millan reported that the addition of TENS at the P6 (Neiguan) acupuncture point to usage of ondansetron as an antiemetic significantly increases the antiemetic effect of the drug (12).

    This study found acustimulation by use of the Reliefband to be an adequate nausea and vomiting prophylactic, but from the point of patient view of satisfaction, midazolam was found to be a more effective therapy. Although midazolam was less effective than acustimulation for nausea and vomiting, patient satisfaction was higher due to its effect of transient amnesia.

    In conclusion, acustimulation is a good alternative to drug therapy for nausea and vomiting due to its advantages of ease of application, absence of side-effects, cost-effectiveness and variety of use.
  • Top
  • Summary
  • Introduction
  • Materials And Methods
  • Discussion
  • Conclusion
  • References
  • Conclusion
    Demographic characteristics of the groups were not different (p>0.05) (Table 1).

    Table 1: Hemodynamic parameters of before gastroscopy(X±SD)

    Oropharyngeal sensivity and emotional statusMean arterial pressure (MAP) and pulse recorded prior to gastroscopy showed no variance between groups (p>0.05) (Table 2).

    Table 2: During gastroscopy nausea and vomiting (X±SD)

    The difference of oropharyngeal sensitivity and emotional status between groups was not significant (p>0.05) (Table 3).

    Table 3: Patient satisfaction about nausea and vomiting after gastroscopy

    Nausea and vomiting evaluated by Bellivalli scoring in Group RB was less significant than Group C (p<0.05) (Table 4).

    Patient satisfaction in Group M was significant compared to Group RB and Group C and also in Group RB compared to Group C (p<0.01) (p<0.001) (Table 5).
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  • Summary
  • Introduction
  • Materials And Methods
  • Discussion
  • Conclusion
  • References
  • References

    1) .Dundee JW, Ghaly RG. Effect of stimulation of P6 antiemetic point on PONV. Br J Anaesth 1989; 63: 612-8.

    2) .Dundee JW, Chesnut WN, Ghaly RG. Traditional Chinese acupuncture: A potentially useful antiemetic. Br Med J 1986; 293: 583-4.

    3) .Tekeoğlu İ. Akupunkturun tarihçesi. Acar Matbaacılık, 1988; 1-2.

    4) .Tavlan A, Baltacı B, Alptekin A, ve ark. Jinekolojik laparaskopide tek doz ondansetron ve P6 (Neiguan) akupunktur noktasınının bulantı kusmaya etkisinin karşılaştırılması. Tıp ve Sağlık 1997; 1: 48-52.

    5) .Ghaly RG, Fitzpatrick KTJ. Antiemetic studies with traditional Chinese acupuncture. A comparison of manual needling with electrical stimulation and commonly used antiemetics. Anaesthesia 1987; 42: 1108-10.

    6) .Dundee JW, Mc Millan C. Positive evidence for P6 acupuncture antiemesis. Postgrad Med J 1991; 67: 417-22.

    7) .Erickson M, Sjolund B. Acupuncture like electro-analgesia in TENS resistant chronic pain. Functions of the skin. Pergman press, Oxford 1976; 575-81.

    8) .Reliefband: The postable discomfort/pain supression unit. Mavens Labs, Inc, CA.

    9) .Fasuolaki A, Papilas K, Saratopoulos C, Zotou M. Transcutaneous electrical nerve stimulation reduces the incidence of vomiting after hysterectomy. Anesh Analg 1993; 76: 1012-4.

    10) .Dundee JW, Yang J, Mc Milan C. Noninvasive stimulation of the P6 (Neiguan) antiemetic acupuncture point in cancer chemotherapy. Royal Soc Med 1991; 84: 210-2.

    11) .Saller R, Hellenbrecht D, Bühring M, Hess H. Enhancement of the antiemetic action of metoclopramide against cisplatin-induced emesis by transdermal electrical nerve stimulation. J Clin Pharmacol 1986; 26: 115-9.

    12) .Mc Millan C, Dundee JW, Abram WP. Enhancement of the antiemetic action of ondansetron by transcutaneous electrical stimulation of the P6 antiemetic point, in patients having highly emetic cytotoxic drugs. Br J Cancer 1991; 64: 971-2.

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  • Summary
  • Introduction
  • Materials And Methods
  • Discussion
  • Conclusion
  • References
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